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Scientific Reference

  1. Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report. March 10, 2017. Vol. 66. No. 9.
  2. Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham CO 3rd, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, Lisse J, Furst DE, Reda DJ, Moskowitz RW, Williams HJ, Clegg DO. The effect of glucosamine and/or chondroitin sulfate on the progression of knee OA: a report from the glucosamine/chondroitin arth intervention trial. Arth Rheum. 2008 Oct;58 (10):3183-91. doi: 10.1002/art.23973.
  3. Ian J. Wallace, Steven Worthington, David T. Felson, Robert D. Jurmain, Kimberly T. Wren, Heli Maijanen, Robert J. Woods, and Daniel E. Lieberman. Knee OA has doubled in prevalence since the mid-20th century. Anthropology. August 14, 2017. doi.org/10.1073/
  4. Tamer TM. Hyaluronan and synovial joint: function, distribution and healing. Interdiscip Toxicol. 2013;6(3):111-125. doi:10.2478/intox-2013-0019
  5. Necas, J., Bartosikova, L., Brauner, P., & Kolar, J. (2008). Hyaluronic acid (hyaluronan): A review. Veterinarni Medicina, 53(8), 397–411. doi.org/10.17221
  6. Ingram KR, Wann AK, Angel CK, Coleman PJ, Levick JR. Cyclic movement stimulates hyaluronan secretion into the synovial cavity of rabbit joints. J Physiol. 2008;586(6):1715-1729. doi:10.1113/jphysiol.2007.146753
  7. J R Levick. Physiology, Basic Medical Sciences, St. George's Hospital Medical School, Hyaluronan, the guardian of joints. Physiology News Magazine. [2007]. Issue 67. doi.org/10.36866/pn.67.18
  8. Oe, M., Tashiro, T., Yoshida, H. et al. Oral hyaluronan relieves knee pain: a review. Nutrition Journal 15, 11 (2015). doi.org/10.1186/s12937-016-0128-2
  9. Jung H. Hyaluronidase: An overview of its properties, applications, and side effects. Arch Plast Surg. 2020;47(4):297-300. doi:10.5999/aps.2020.00752
  10. Temple-Wong MM, Ren S, Quach P, et al. Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. Arth Res Ther. Published 2016 Jan 21. doi:10.1186/s13075-016-0922-4
  11. Nicholls MA, Fierlinger A, Niazi F, Bhandari M. The Disease-Modifying Effects of Hyaluronan in the OA Disease State. Clin Med Insights Arth Musculoskelet Disord. 2017. doi:10.1177/1179544117723611
  12. Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee OA: a double-blind, placebo-controlled study over a 12-month period. Scientific World Journal. 2012. doi: 10.1100/2012/167928.
  13. Möller I, Martinez-Puig D, Chetrit C. Oral administration of a natural extract rich in hyaluronic acid for the treatment of knee OA with synovitis: a retrospective cohort study. Clinical Nutrition Supplements 2009.
  14. Douglas S Kalman, Maria Heimer, Anita Valdeon, Howard Schwartz and Eric Sheldon. Effect of a natural extract of chicken combs with a high content of hyaluronic acid on pain relief and quality of life in subjects with knee OA: a pilot randomized double-blind placebo-controlled trial. Nutrition Journal 2008
  15. Martinez-Puig D, Möller I, Fernández C, Chetrit C. Efficacy of oral administration of yoghurt supplemented with a preparation containing hyaluronic acid (Mobilee™) in adults with mild joint discomfort: a randomized, double-blind, placebo controlled intervention study. Mediterranean Journal of Nutrition and Metabolism 2013;6:63–68.
  16. Sánchez J, Bonet ML, Keijer J, van Schothorst EM, Mölller I, Chetrit C, Martinez-Puig D, Palou A. Blood cell transcriptomics as a source of biomarkers of articular health. Annals of Nutrition and Metabolism 2013;63(S1):538
  17. Moriña D, Solà R, Valls RM, López de Frutos V, Montero M, Giralt M, Papell I, Bernal G, Faba J, Casajuana C, Rodríguez A, Chetrit C, Martinez-Puig, Efficacy of a Low-fat Yogurt Supplemented with a Rooster Comb Extract on Joint Function in Mild Knee Pain Patients: A Subject-level Meta-analysis. Annals of Nutrition and Metabolism 2013;63(S1):1386
  18. Rohdewald PJ. Review on Sustained Relief of OA Symptoms with a Proprietary Extract from Pine Bark. J Med Food. 2018;21(1):1-4. doi:10.1089/jmf.2017.0015
  19. Cisár P, Jány R, Waczulíková I, Sumegová K, Muchová J, Vojtassák J, Duraćková Z, Lisý M, Rohdewald P. Effect of pine bark extract on symptoms of knee OA. Phytother Res. 2008 Aug;22(8):1087-92. doi: 10.1002/ptr.2461.
  20. Mulek et al. "Distribution of Constituents and Metabolites of Maritime Pine Bark Extract into Serum, Blood Cells, and Synovial Fluid of Patients with Severe OA: A Randomized Controlled Trial". Nutrients. 2017. Doi:10.3390/nu9050443
  21. Rohdewald, Peter Jörg. "Review on Sustained Relief of OA Symptoms with a Proprietary Extract from Pine Bark." Journal of Medicinal Food. V 21,1 (2018): 1-4. doi:10.1089/jmf.2017.0015
  22. Cisár P, Jány R, Waczulíková I, Sumegová K, Muchová J, Vojtassák J, Duraćková Z, Lisý M, Rohdewald P. Effect of pine bark extract on symptoms of knee OA. Phytother Res. 2008 Aug;22(8):1087-92. doi: 10.1002/ptr.2461.
  23. Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with OA. Arthr Rheum. 2001 Nov;44(11):2531-8. doi: 10.1002/1529-0131 (200111)
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  25. Bartels EM, Folmer VN, Bliddal H, Altman RD, Juhl C, Tarp S, Zhang W, Christensen R. Efficacy and safety of ginger in OA patients: a meta-analysis of randomized placebo-controlled trials. OA Cartilage. 2015 Jan;23(1):13-21. doi: 10.1016/j.joca.2014.09.024.
  26. Yu G, Xiang W, Zhang T, Zeng L, Yang K, Li J. Effectiveness of Boswellia and Boswellia extract for OA patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2020 Jul 17;20(1):225. doi: 10.1186/s12906-020-02985-6.
  27. Siddiqui MZ. Boswellia serrata, a potential anti-inflammatory agent: an overview. Indian J Pharm Sci. 2011 May;73(3):255-61. doi: 10. 4103/0250-474X.93507.